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Adrenal Transformation Protocol: A 4-Week Plan to Release Stress Symptoms and Go from Surviving to Thriving Hardcover – April 18, 2023
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What were you doing in your life before you got sick? This is a common question Dr. Izabella Wentz asks her functional medicine clients when trying to get to the root cause of symptoms ranging from low energy, to dependency on caffeine, to sleeplessness and poor memory. More often than not, she finds these individuals developed their symptoms after a period of acute or chronic stress: starting a new business, having a baby, living though a global pandemic—these can all destroy our once-resilient stress response.
Since her own diagnosis of Hashimoto’s thyroiditis at the age of twenty-seven and subsequent bestselling books, Dr. Wentz has become known for her passion to translate emerging research in order to help patients eliminate symptoms conventional medicine has failed to address or even acknowledge. With Adrenal Transformation Protocol, Dr. Wentz tackles adrenal dysfunction, or the body’s inability to produce essential hormones when it mismanages stress. While adrenal dysfunction produces a constellation of ailments, the good news is that turning these around does not have to be complicated. When we start supporting the adrenals—making a few small dietary and lifestyle changes and taking the right supplements—we can produce profound improvements within weeks or even days.
With a simple 4-week program to help identify your adrenal triggers, balance your stress response, and gradually build up your resilience to prevent excess stress from overwhelming your adrenals in the future, The Adrenal Transformation Protocol will set you up with a strong foundation to return to and stay in homeostasis through turbulence.
- Print length400 pages
- LanguageEnglish
- PublisherAvery
- Publication dateApril 18, 2023
- Dimensions6.17 x 1.3 x 9.25 inches
- ISBN-100593420772
- ISBN-13978-0593420775
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From the Publisher



Editorial Reviews
Review
"Once again, Izabella translates complicated science into an actionable, research-supported, completely life-changing plan. Using the foundation of food as medicine, this book will help you overcome the debilitating symptoms of adrenal dysfunction and feel energized, clearheaded, and strong again."--Mark Hyman, MD, New York Times bestselling author of The Pegan Diet
"Dr. Izabella Wentz is a thought leader and unparalleled researcher who is passionate about digging deeper to understand the true root of our health issues. In this book, she offers the most comprehensive look at adrenal dysfunction I've read, along with clear strategies to get us back on track. It's a must-have for anyone suffering."--Jolene Brighten, NMD, FABNE, author of Is This Normal? and Beyond the Pill
"If you want to learn how to have the body and mind you want and even manage your stress like a boss, read this book right now. Izabella is a master of the many secrets of your adrenal glands."--Dave Asprey, father of biohacking, founder of Bulletproof, and four-time New York Times bestselling author
"Adrenal dysfunction is a source of suffering among millions of people and yet remains poorly understood by both conventional and alternative medical practitioners. Dr. Wentz's book is an excellent resource that integrates the valid science behind adrenal dysfunction with evidence-based and safe lifestyle changes. She shows that hope is possible and has created an excellent protocol that can help guide people back to thriving."--Alan Christianson, NMD, New York Times bestselling author of The Adrenal Reset Diet
About the Author
Excerpt. © Reprinted by permission. All rights reserved.
"You're just getting older." I was in my twenties when I heard this gem.
"Maybe you need antidepressants." But I'm not depressed. I just have these weird panic attacks that come out of nowhere.
"Your lab tests are normal." But they didn't do the right ones, and at the time, I didn't know any better.
Finally in 2009, after finding a doctor who was willing to do more comprehensive lab testing for me, I was diagnosed with Hashimoto's thyroiditis. Hashimoto's is an autoimmune condition in which the immune system recognizes the thyroid gland as a foreign invader, eventually leading to enough thyroid, damage, so that the thyroid is unable to function properly and cannot produce enough thyroid hormones.
Thyroid hormones regulate metabolism, heart rate, digestion, blood pressure, the menstrual cycle, and body temperature, among other important roles. Every single cell in our bodies depends on thyroid hormones in some way, so when our thyroids are out of balance, we feel it everywhere.
As a pharmacist, I knew a thing or two about the thyroid, but in full disclosure, I thought hypothyroidism was a super boring condition, with just one drug to treat it (levothyroxine). If you had told me that I would one day become the "Thyroid Pharmacist," I would have surely laughed! But of course, the universe had its own plan. After my own diagnosis, I was dissatisfied that the only recommendation from my well-meaning conventional doctors was to take synthetic thyroid hormone replacement pills. Of course, as a pharmacist, I fully support using medication when needed to improve outcomes, but I was also taught the value of lifestyle interventions in pharmacy school.
I was excited to start on thyroid medications, and while meds helped a little, I still did not feel 100 percent well. I wanted to do everything in my power to feel like myself again, so my next step was clear: to find a set of lifestyle interventions that would get me 100 percent better.
I reviewed the latest scientific research, online patient forums, and various health books. I consulted with numerous medical experts across a range of disciplines and healing modalities. I turned myself into a human guinea pig and tracked the outcomes of various interventions. After a lot of trial and error, I was able to remarkably improve my health and get my condition into remission through addressing the many imbalances that are present in Hashimoto's, beyond a deficiency in thyroid hormones. They include food sensitivities, blood sugar imbalances, infections, intestinal permeability, nutrient deficiencies, an impaired ability to handle toxins, and, last but not least, an impaired stress response, also known as adrenal dysfunction. I know that addressing these issues can produce profound healing, and it has been my goal to distill the information from emerging research, the insights of functional medicine theory and testing, and my personal and client experiences into accessible self-help guides for self-healers like yourself.
Today, I am able to help others heal because I have healed myself. But to get there, I had to shed a bit of ego and skepticism that initially delayed my own healing.
When my integrative doctor suggested I get tested for adrenal fatigue, I was skeptical. Like most conventionally trained healthcare professionals, I was only familiar with one type of adrenal issue, known as Addison's disease, an autoimmune condition that is life-threatening and requires lifelong use of medications for survival.
When I searched "Dr. Google," I found that "adrenal fatigue" was considered a bogus, "quack" diagnosis. I thought that I knew better, and didn't want to be tricked, so I delayed testing my own adrenals for a long time. It wasn't until I spoke with another pharmacist, Carter Black, RPh (who would later become a wonderful friend and collaborator), about my lingering symptoms and he suggested adrenal testing that I decided to give it a try. Maybe I was more open to it because we had similar training and he wasn't trying to sell me anything, or maybe the timing was just right. I like to think that it was destiny. Sure enough, the integrative adrenal test showed that I had an advanced stage of adrenal dysfunction. I followed the recommended protocols and saw incredible improvements in my energy levels, emotional state, blood sugar issues, and hormone balance-quickly! A lightbulb went off in my head: This works and actually helps!
The Functional Medicine Approach
I wanted to know more about the "how and why" behind these strategies, so I dug deeper into the physiology of the body's stress response and read every book and took every course I could find on the topic. I enrolled in a six-month mentorship training program with Dr. Dan Kalish, a leading voice in stress response protocols, and studied the writings of Dr. James L. Wilson, who coined the term "adrenal fatigue," Dr. Thomas Guilliams, an expert on stress and the HPA axis and the author of The Role of Stress and the HPA Axis in Chronic Disease Management, and the late William G. Timmins, ND, founder of BioHealth Diagnostic and author of The Chronic Stress Crisis.
According to Dr. Timmins, the chronic stress response is the body's way of adapting to any kind of stress. In the early phases of chronic stress, the brain and hormonal system pump out large amounts of cortisol. However, as time goes on, the brain and hormone-making organs begin to downregulate (or minimize) cortisol production to self-preserve, and this leads to low levels of circulating cortisol. I like to call it the "Boy Who Cried Wolf Syndrome." The adrenals were serving up an emergency response to stress but eventually became desensitized to it so that cortisol production remains low.
I learned how the adrenals interact with the hypothalamus and pituitary gland in what's referred to as the hypothalamic-pituitary-adrenal axis, or HPA axis. A communication breakdown among these three, often due to chronic stress, can impair the body's ability to respond to stress in a healthy way and unbalance several hormones produced in the adrenals such as cortisol, progesterone, and estrogen. This is what can lead to the symptoms I was experiencing, not the adrenals actually being tired.
The more I researched and studied, the more I appreciated the functional medicine approach to adrenal support based heavily on specific lifestyle changes, such as cutting out caffeine, eating for blood sugar balance, and getting lots of sleep (ten to twelve hours!).
The approach also utilizes targeted supplements, most notably the ABCs of adrenal support: adaptogens (herbs that raise the body's resilience to various types of stress), B vitamins, and vitamin C. Additionally, supplements can be used to modify the levels of dehydroepiandrosterone (DHEA) and cortisol, the two most important adrenal hormones. Levels are modified directly through hormone supplements like DHEA and pregnenolone, and/or hydrocortisone, and/or indirectly with magnesium to boost DHEA, licorice to increase cortisol, and/or phosphatidylserine to decrease cortisol.
This approach has worked really, really well for me and for many of my clients with Hashimoto's. As a pharmacist who is passionate about helping others heal, I felt that I really needed to get this healing information to more people, so I shared guidance on adrenal protocols based on these fundamentals in my books Hashimoto's Thyroiditis: Lifestyle Interventions for Finding and Treating the Root Cause (2013) and Hashimoto's Protocol: A 90-Day Plan for Reversing Thyroid Symptoms and Getting Your Life Back (2017). I have been so humbled by how my own healing journey turned into thousands of healing stories from people around the world who have been able to take charge of their health by using the guides I have written.
In my books, I focused heavily on lifestyle and supplements, as I was limited in my ability to offer specific advice about DHEA, pregnenolone, and hydrocortisone hormone supplementation. During my training I learned that these hormones can have many contraindications and proper use and dosing requires testing therefore, hormone therapy should only be undertaken with the guidance of a trained professional. Fortunately, the lifestyle and self-care strategies I was able to share still got great results under the right circumstances.
Since developing my initial protocols, I've grown tremendously as a healer. I love to learn from everything and everyone. I am always finding new research, working with clients with unique challenges, taking courses, trying out new interventions on myself, and thinking about how to get more people to feel their absolute best. Equally important, I became a mother and I have to say that my son truly has been my greatest teacher. Since becoming a mom, I have been humbled by motherhood, moms all over the world, and the resilient human spirit. I have learned a great deal about surviving and thriving and the power of oxytocin (the "love hormone") and life's simple pleasures in healing. I've also realized that while some people can undertake intensive lifestyle changes, others need additional healing modalities and gentle options to heal.
As a result, my approach to the adrenals has evolved, just as I have. What I've realized over time is that under the right circumstances the original functional medicine protocols work really, really well but that these interventions are not always possible, feasible, or safe for everyone, every time. So I developed additional protocols that utilized different pathways to produce healing results (and was so excited when I realized that the new protocols often worked even better).
My Original Adrenal Recommendations in Hashimoto's Protocol
When I originally created the Adrenal Recovery Protocol, these were the main pillars:
Rest: Committing to ten to twelve hours of sleep each night for at least two weeks and kicking caffeine to promote restorative sleep.
De-stress: Using stress-reducing techniques such as gentle exercise and thinking positive to shift the body into a state of relaxing.
Reduce inflammation: Following the Root Cause Paleo Diet to lower the intake of inflammatory foods and increase the intake of anti-inflammatory food.
Balance the blood sugar: Limiting carbohydrates and focusing on eating fats, proteins, and veggies to maintain stable blood sugar.
Replenish nutrients and add adaptogens: Adding adaptogenic herbs, B complex vitamins, and vitamin C (the ABCs of adrenal balancing) as well as selenium and magnesium.
This approach can provide excellent results under the right circumstances, but, as I've grown as a healer, I've realized that there are additional healing modalities better suited for the real-world challenges of modern life that can provide even better outcomes for more people. The Adrenal Transformation Protocol incorporates everything I've learned since developing my initial adrenal recommendations to help you heal and thrive.
Product details
- Publisher : Avery (April 18, 2023)
- Language : English
- Hardcover : 400 pages
- ISBN-10 : 0593420772
- ISBN-13 : 978-0593420775
- Item Weight : 2.31 pounds
- Dimensions : 6.17 x 1.3 x 9.25 inches
- Best Sellers Rank: #51,709 in Books (See Top 100 in Books)
- #18 in Endocrine System Diseases
- #25 in Thyroid Conditions
- #218 in General Women's Health
- Customer Reviews:
About the author

Dr. Izabella Wentz, PharmD, FASCP is an internationally acclaimed thyroid specialist and licensed pharmacist who has dedicated her career to addressing the root causes of autoimmune thyroid disease, fatigue and mystery illnesses after being diagnosed with Hashimoto’s thyroiditis in 2009.
Dr. Wentz is the author of the New York Times best-selling patient guide Hashimoto’s Thyroiditis: Lifestyle Interventions for Finding and Treating the Root Cause, the #1 New York Times best-selling protocol-based book Hashimoto’s Protocol: A 90-Day Plan for Reversing Thyroid Symptoms and Getting Your Life Back, Hashimoto's Food Pharmacology: Nutrition Protocols and Healing Recipes to Take Charge of Your Thyroid Health, and Adrenal Transformation Protocol: A 4-Week Plan to Release Stress Symptoms and Go from Surviving to Thriving.
Website: www.thyroidpharmacist.com
Instagram: instagram.com/izabellawentzpharmd
Facebook: www.facebook.com/thyroidlifestyle
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Learn more how customers reviews work on AmazonCustomers say
Customers find the book helpful for understanding health and wellness issues. They find the information easy to understand and follow, with a simple approach. The book is relatable with enjoyable narratives and honest personal stories. Readers praise the author as an excellent writer who writes well and includes helpful graphics.
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Customers find the book helpful for their health journeys. They say it provides valuable information on diet and lifestyle changes to heal burnout and adrenal issues. The book is described as a perfect combination of science and heart, with helpful information presented in an easy-to-follow format.
"...pharmaceutical medicine with a respectable and effective accompaniment of vitamins, herbs and life style changes to get to her own personal robust..." Read more
"...also diet, lifestyle changes, thoughts, habits and a general approach to a balanced life, healing the constant overriding of our inner signals that..." Read more
"...She shares what works and what doesn't work, and covers food, nutrients/supplements, infections, lifestyle and simple mind–body practices..." Read more
"...Her discussion of supplements is very helpful, and her stressing the importance of good sleep is impeccable...." Read more
Customers find the book easy to understand and follow. It provides a comprehensive guide with clear strategies. The author makes complex medical topics accessible for the layperson without trivializing their struggles. Readers find the information presented in a straightforward manner.
"...clinical training as a pharmacist to put together a go-to and easy to read book to help both males and females who have been struggling with either..." Read more
"...This book is amazing. It’s a complete guide that focuses on more than just supplements..." Read more
"...A veritable gold-mine of a book with almost 400 pages of useful information...." Read more
"...The strengths of the “Adrenal Transformation Protocol” are the easy-to-follow steps and the food suggestions and recipes. This is a workbook...." Read more
Customers find the book relatable and enjoyable. They appreciate the common sense and honest approach to the author's journey.
"...of age and educational background - it's just common sense and enjoyable narratives, examples and go-to information." Read more
"...Izabella is vulnerable and honest regarding her own journey and uses her huge social media following to produce a remarkable book...." Read more
"...(personal stories make this journey even more real and relatable) and consume but also to implement. Another wonderful book from her...." Read more
"This book is the perfect combination of science and heart. It’s entirely relatable and her protocol is absolutely sustainable, long-term." Read more
Customers appreciate the book's writing style. They find it comprehensive, well-written, and easy to understand.
"Izabella Wentz has done it again. Izabella is a proficient author and researcher able to take complex problems and simplify steps toward healing...." Read more
"Comprehensive, well written, easy to understand and follow...." Read more
"Well written..." Read more
"Excellent content. Excellent writer...." Read more
Customers like the color scheme of the book. They say it has breathing practices, a beautiful mandala butterfly to color, and helpful graphics that help understand the content.
"...oxytocin feel-good levels, breathing practices, and a beautiful mandala butterfly to color)...." Read more
"...already been using it in my practice and my patients love the helpful graphics that help you understand our adrenals and stress hormone, cortisol...." Read more
"Beautiful, very thorough and practical - any person with chronic stress needs this resource..." Read more
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A good book for those new to the wellness journey
Top reviews from the United States
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- Reviewed in the United States on January 13, 2025Dr. Wentz has used her clinical training as a pharmacist to put together a go-to and easy to read book to help both males and females who have been struggling with either thyroid issues or confusing stress health challenges.
She has scaffolded the research that she personally had to dig up to put together a health regime that addressed causative vectors of a challenging array of health issues. Dr. Wentz has had the courage to bridge current and historic research in both mainstream pharmaceutical medicine with a respectable and effective accompaniment of vitamins, herbs and life style changes to get to her own personal robust health regime.
In a prior book called Hashimoto's Protocol she did a terrific job of helping people of either gender and any age move beyond mainstream medicine's attachment to simply treat thyroid challenges with various levels of T4 medication.
With her most recent book, Adrenal Transformation Protocol she has closed the loop and woven effective support for both women and men for stress and thyroid issues into a less confusing and less test weary approach that individual with a bit of courage and common sense can navigate themselves.
She recognizes that the constant barrage of environmental chemicals, noise, information stimulation overload and hormonal shifts experienced by both genders at various stages of age can be moved out from the sad umbrella of anti-depression medication and ineffective thyroid treatments into a comprehensible do-it-yourself-with dignity protocol. It's a terrific watershed in personal healthcare, and it's easily read by anyone regardless of age and educational background - it's just common sense and enjoyable narratives, examples and go-to information.
- Reviewed in the United States on April 25, 2023I first heard of Isabella from Will Cole’s podcast and everything she was saying resonated so much with my experience of trying to recover from adrenal fatigue over the last five years or so that I had to buy the book even if I was skeptical about all the immediate 5-star reviews. (And the promise of healing in 4 weeks.)
Let me tell you - the reviews are legit. This book is amazing.
It’s a complete guide that focuses on more than just supplements (unfortunately a lot of integrative docs focus too much on this to the exclusion of other healing things like morning sunlight).
She covers supplements, but also diet, lifestyle changes, thoughts, habits and a general approach to a balanced life, healing the constant overriding of our inner signals that often leads to adrenal fatigue in the first place.
She explains WHY things are necessary, but not in overly scientific terminology that’s difficult to understand. I love this because I’m someone that likes to customize things, and you can only do that if you understand the why behind the what.
It also means you don’t need every single supplement she recommends because you understand how to use food to fill that need instead.
It also helps when you’re not feeling good. The other day I felt unwell, looked at her table of symptoms to figure out what might be imbalanced, made myself a smoothie with the nutrients she said were probably off, and immediately felt better!
It’s just so incredibly wonderful to have this as a guidebook by my side to support my journey of healing. I’ve healed and relapsed several times over the years, but am very hopeful that with this book’s combination of helping me understand why I feel the way I do and the exact things to do to heal, that I will finally heal and get my life back.
Anyone who’s skeptical, just buy the book. Take her advice. Dr. Wentz knows the way.
- Reviewed in the United States on April 28, 2023Feeling stressed, rundown, and overwhelmed or struggling with outright fatigue seem to be epidemic these days.
Dr. Izabella Wentz has just gifted us with her newest book, Adrenal Transformation Protocol, that is jam-packed with scientific explanations of the myriad causes of fatigue and how the body responds. At the same time, it provides so many simple and accessible action items to help restore vitality.
This is a true romp through Functional Medicine root causes and how to address them. A veritable gold-mine of a book with almost 400 pages of useful information.
Dr. Wentz learned the hard way much of the material she shares: on herself! She shares what works and what doesn't work, and covers food, nutrients/supplements, infections, lifestyle and simple mind–body practices (like gratitude - known to increase oxytocin feel-good levels, breathing practices, and a beautiful mandala butterfly to color).
She has an important section that really spoke to me: Saying No! And more valuable advice: give yourself more permission to do things you enjoy.
This book has been in the top 100 books on all of Amazon since it launched, and was ranking number 28 a few days ago! So it's clearly speaking to people in need. 
I'm really happy to have this valuable resource to recommend to my patients!
Kat Toups, MD
5.0 out of 5 starsFeeling stressed, rundown, and overwhelmed or struggling with outright fatigue seem to be epidemic these days.Gold-Mine of a Book for the Epidemic of Stress/Fatigue/Overwhelm
Reviewed in the United States on April 28, 2023
Dr. Izabella Wentz has just gifted us with her newest book, Adrenal Transformation Protocol, that is jam-packed with scientific explanations of the myriad causes of fatigue and how the body responds. At the same time, it provides so many simple and accessible action items to help restore vitality.
This is a true romp through Functional Medicine root causes and how to address them. A veritable gold-mine of a book with almost 400 pages of useful information.
Dr. Wentz learned the hard way much of the material she shares: on herself! She shares what works and what doesn't work, and covers food, nutrients/supplements, infections, lifestyle and simple mind–body practices (like gratitude - known to increase oxytocin feel-good levels, breathing practices, and a beautiful mandala butterfly to color).
She has an important section that really spoke to me: Saying No! And more valuable advice: give yourself more permission to do things you enjoy.
This book has been in the top 100 books on all of Amazon since it launched, and was ranking number 28 a few days ago! So it's clearly speaking to people in need. 
I'm really happy to have this valuable resource to recommend to my patients!
Kat Toups, MD
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Top reviews from other countries
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Karla Lucero Peña MorenoReviewed in Mexico on July 24, 2023
5.0 out of 5 stars ATP-Healing Journey
Elegí 5 estrellas para el libro al ser la única guía confiable en mi viaje con resistencia a la insulina y posible SOP. La autora cita sus fuentes de información y permite que el lector indague más… Este libro es reafirmar que mis síntomas sí eran reales y sanarlos también.
- Stephanie D.Reviewed in Canada on April 18, 2023
5.0 out of 5 stars Great read
I've struggled with my adrenals for years. When I first started following Dr. Wentz, I was interested in her "Hashimoto's Protocol" book. It has a section on healing the adrenals, which I followed. A couple years later, now, I find that I need to support my adrenals again. Just started reading this book, Adrenal Transformation Protocol, and can I just say "wow!". There is so much information, and so many tools and prompts to journal in here, it's absolutely amazing. I'm so excited to start this protocol asap! Thanks so much!
- JulieReviewed in the United Kingdom on October 6, 2023
5.0 out of 5 stars Recommend
I found this book very informative and it's really helped me to understand my body and it's immballaces, I have been following the protocol to heal myself and bring balance back into my life and I am certainly much improved. I recommend this book and advice you read it all and not skip any part to get the most benefit
- Mrs Fiona J FinsterReviewed in Australia on November 5, 2023
5.0 out of 5 stars Another side to the story
Great to hear a different perspective. Very clear and detailed. Loved how she explained the situation and how to improve.
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EvelinReviewed in Mexico on July 1, 2023
5.0 out of 5 stars BONITO
LLEGO en perfectas condiciones. Y es muy util