Other Sellers on Amazon
91% positive over last 12 months
- 3 VIDEOS
Image Unavailable
Color:
-
-
-
- To view this video download Flash Player
NOW Supplements, SAMe (S-Adenosyl-L-Methionine) 400 mg, Nervous System Support*, 60 Tablets
Purchase options and add-ons
Brand | NOW |
Flavor | Unflavored |
Primary Supplement Type | multivitamin |
Unit Count | 60 Count |
Item Form | Tablet |
Item Weight | 3.17 ounces |
Item Dimensions LxWxH | 2.13 x 2.13 x 4 inches |
Diet Type | Gluten Free |
Product Benefits | Bone & Joint Support |
Age Range (Description) | Adult |
About this item
- NEW OVAL TABLET!: SAMe (S-adenosylmethionine), a compound native to the body, is a component of many biochemical reactions, including those that affect brain biochemistry and joint health.*
- SUPPORTS NERVOUS SYSTEM, EMOTIONAL WELL-BEING, AND JOINT HEALTH*: Numerous studies have indicated that SAMe can help to alleviate transient minor aches and pains resulting from overexertion or strain.* In addition, because SAMe is also necessary for the synthesis of neurotransmitters, it plays an important role in mood support.*
- CERTIFICATIONS/CLASSIFICATIONS: Dairy Free, Egg Free, Made without Gluten, Soy Free, Sugar Free, Vegan/Vegetarian
- GMP Quality Assured: NPA A-rated GMP certification means that every aspect of the NOW manufacturing process has been examined, including our laboratory/testing methods (for stability, potency, and product formulation).
- Packaged in the USA by a family owned and operated company since 1968
- During the summer months products may arrive warm but Amazon stores and ships products in accordance with manufacturers' recommendations, when provided.
Frequently bought together
Similar items that may deliver to you quickly
- Doctor's Best SAM-e 400 mg, Vegan, Gluten Free, Soy Free, Mood and Joint Support, 60 Enteric Coated TabletsFREE Shipping by AmazonGet it as soon as Tuesday, Mar 26
- Pure Sam E Vitamin Supplement - Sam-E 400mg Per Serving Memory Supplement for Brain Support Mood Boost Joint Health and Liver Support - Brain Boost Nootropic Supplement and Natural Supplement - 90ctFREE Shipping on orders over $35 shipped by AmazonGet it as soon as Tuesday, Mar 26
- NOW Supplements, SAMe (S-Adenosyl-L-Methionine)200 mg, Nervous System Support*, 120 Veg CapsulesAmazon's Choicein 5-HTP Nutritional SupplementsFREE Shipping by AmazonGet it as soon as Tuesday, Mar 26
- Nature Made SAM-e Complete 400 mg, Dietary Supplement for Mood Support, 36 Tablets, 36 Day SupplyFREE Shipping on orders over $35 shipped by AmazonAmazon's Choicein Blended Vitamin & Mineral SupplementsOnly 1 left in stock - order soon.
From the manufacturer
Product Description
Product Description
SAMe (S-adenosylmethionine), a compound native to the body, is a component of many biochemical reactions, including those that affect brain biochemistry and joint health.* Numerous studies have indicated that SAMe can help to alleviate transient minor aches and pains resulting from overexertion or strain.* In addition, because SAMe is also necessary for the synthesis of neurotransmitters, it plays an important role in mood support.* NOW® SAMe is enteric-coated, which makes it very well tolerated and protects it from degradation. Natural color variation may occur in this product. Take 1 tablet 2 to 4 times daily, preferably on an empty stomach. Refrigeration recommended after opening.
Brand Story
By
Product details
- Is Discontinued By Manufacturer : No
- Product Dimensions : 2.13 x 2.13 x 4 inches; 3.17 ounces
- Item model number : 0141
- Department : Health and Beauty>Health and Wellness
- Date First Available : October 3, 2006
- Manufacturer : NOW Sports - Nutrition and Wellness
- ASIN : B000OSSQFY
- Country of Origin : USA
- Best Sellers Rank: #28,902 in Health & Household (See Top 100 in Health & Household)
- #1,207 in Blended Vitamin & Mineral Supplements
- #2,681 in Sales & Deals
- Customer Reviews:
Compare with similar items
This Item NOW Supplements, SAMe (S-Adenosyl-L-Methionine) 400 mg, Nervous System Support*, 60 Tablets | Recommendations | dummy | dummy | dummy | dummy | |
Try again! Added to Cart | Try again! Added to Cart | Try again! Added to Cart | Try again! Added to Cart | Try again! Added to Cart | Try again! Added to Cart | |
Price | -41% $42.79$42.79 List: $71.99 | -15% $23.99$23.99 List: $28.22 | $35.95$35.95 | -13% $23.77$23.77 List: $27.34 | $18.97$18.97 | -44% $34.75$34.75 List: $62.19 |
Price Per Unit | $0.71 / Count | $0.40 / Count | $0.30 / Count | $0.40 / Count | $0.32 / Count | $0.97 / Count |
Delivery | Get it as soon as Tuesday, Mar 26 | Get it as soon as Tuesday, Mar 26 | Get it as soon as Tuesday, Mar 26 | Get it as soon as Tuesday, Mar 26 | — | — |
Customer Ratings | ||||||
Easy to swallow | 4.2 | 4.3 | 4.2 | 4.7 | 4.7 | 4.2 |
Pain relief | 3.0 | 3.2 | 3.5 | 4.0 | — | 3.5 |
Value for money | 3.7 | — | — | 4.8 | 4.4 | 3.8 |
Flavor | — | 4.0 | 4.2 | 4.5 | 4.0 | — |
Sold By | Amazon.com | Carlyle | eSupplements | Natures Craft Deals | Motivated Mindset | Certified Wholesale Market |
keyword type | multiple-vitamin-mineral-combinations | multiple-vitamin-mineral-combinations | multiple-vitamin-mineral-combinations | multiple-vitamin-mineral-combinations | elderberry-herbal-supplements | multiple-vitamin-mineral-combinations |
form | Tablet | Tablet | Capsule | Capsule | Gummy | Tablet |
flavor | Unflavored | — | — | Unflavored | — | No Artificial Flavors |
size | 60 Count (Pack of 1) | 60 Count (Pack of 1) | 120 Count (Pack of 1) | 60 Count (Pack of 1) | 60 Count (Pack of 1) | 36 Count (Pack of 1) |
weight | 0.2 pounds | 5.26 ounces | 0.07 kilograms | 0.01 ounces | — | 0.15 pounds |
age range | Adult | Adult | Adult | Adult | Adult | Adult |
product benefit | Bone & Joint Support | — | — | Detoxing | — | Mood Support,Joint Support |
Videos
Videos for this product
0:30
Click to play video
19,000 Reasons to Feel Good Spending Less
NOW Foods
Videos for this product
0:30
Click to play video
The NOW Quality Difference
NOW Foods
Videos for this product
0:15
Click to play video
19,000 Puppies Is a Lot!
NOW Foods
Important information
Safety Information
For adults only. Keep out of the reach of children. Individuals with bipolar (maniac) depression and these with anxiety disorder should not take SAMe unless under professional medical supervision. Consult physician if pregnant/nursing, taking medication, or have a medical condition. Do not eat freshness packet. Keep in bottle. Refrigeration recommended after opening. Allergen Caution: Product not manufacture with wheat, gluten, soy, milk, egg, fish, shellfish, or tree nut ingredients.This product is labelled to United States standards and may differ from similar products sold elsewhere in its ingredients, labeling and allergen warnings
Ingredients
Supplement FactsServing Size:1 TabletServings Per Container:30DescriptionAmount per Serving% Daily ValueSAMe (S-Adenosyl-L-Methionine)(from S-Adenosyl-L-Methionine Disulfate Tosylate) 400 mg ** Daily Value not established. **Daily Value not established.Other Ingredients: Microcrystalline Cellulose, Stearic Acid (vegetable source), Pharmaceutical Glaze, Magnesium Stearate (vegetable source), Silicon Dioxide, Glycerin, Sodium Alginate and L-Arginine. Not manufactured with wheat, gluten, soy, milk, egg, fish or shellfish ingredients. Produced in a GMP facility that processes other ingredients containing these allergens. Caution: For adults only. Individuals with bipolar depression, anxiety disorders or taking antidepressant medications should not take SAMe unless under professional medical supervision. Consult physician if pregnant/nursing, taking medication, or have a medical condition. Keep out of reach of children. Natural color variation may occur in this product. Made and quality tested in the USA with globally sourced ingredients. Family owned since 1968.
Directions
Take 1 tablet 2 to 4 times daily, preferably on an empty stomach.
Legal Disclaimer
These statements have not been evaluated by the Food & Drug Administration. This products is not intended to diagnose, cure, mitigate, treat, or prevent any disease.
Statements regarding dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease or health condition.
Looking for specific info?
Customer reviews
Customer Reviews, including Product Star Ratings help customers to learn more about the product and decide whether it is the right product for them.
To calculate the overall star rating and percentage breakdown by star, we don’t use a simple average. Instead, our system considers things like how recent a review is and if the reviewer bought the item on Amazon. It also analyzed reviews to verify trustworthiness.
Learn more how customers reviews work on AmazonCustomers say
Customers like the performance, quality and value of the health personal care product. They mention that it helps with mood boost, brings homeostasis to the hypothalamus and that it's the best quality for the money. Customers also say that it makes them feel more calm, peaceful and cheerful. However, some customers differ on stomach pain, and durability.
AI-generated from the text of customer reviews
Customers like the performance of the product. They say it helps with mood boost, improves mood and sleep instantly, and helps their body function. They also mention that it brings homeostasis to the hypothalamus, which helps regulate body temp. Customers also say it gives them energy and calms their nerves. They are surprised with the positive results and say the combination rapidly enhanced cognitive function and prevented or reduced aggression.
"...The combination rapidly enhanced cognitive function and prevented or reduced aggression in the animals, an effect that was rapidly reversed when the..." Read more
"...I gave this a shot and I’m now 1 month in and I’m very surprised with the positive results...." Read more
"...I believe on the second day I noticed an improvement. Mood improved, energy level really improved, and I was able to stay focused without anxiety..." Read more
"I feel Sam-e absolutely helped me with my depression...." Read more
Customers are satisfied with the quality of the health supplement. They mention that it works well, is a reputable brand, and is well-made. Some say that the product arrived in good shape. Overall, customers are happy with their purchase and recommend it to others.
"...Because of its strong safety record, SAMe should be part of any regimen for brain health, particularly when depressive symptoms are present—and when..." Read more
"...Now" brand for a few different things now and it seems to be a pretty reputable brand. I like the nature craft as well." Read more
"...Just smooth and steady, focused and able to live and work 'normally'. I mostly hate normal but sometimes, ya know, ya have to...." Read more
"...The dose was worked out by my vet. They go fairly quickly. More economically feasible to buy these bottles in pairs to save on shipping." Read more
Customers like the value of the health personal care product. They say it provides the best quality for the money.
"...it as a subscribe and save option, which does make it more affordable in monthly increments." Read more
"...It's cheaper, and it's clear that it (in combination with another med from Vet) is doing wonders for my dog!..." Read more
"...a higher dosage of this versus the GNC version but this is also much cheaper and a better value." Read more
"...The NOW brand is quality and a great price.If you have chronic pain and want relief give SAMe a try." Read more
Customers like the effect of the product on their body. They say it makes them feel more calm, peaceful, and cheerful. They also say it helps them feel less anxiety, better sleep, and stabilize their emotions. Customers also mention that the product is not stimulating and just sets them back to normal.
"...No highs or lows, no anxiety, no lethargy, no angry outbursts. Just smooth and steady, focused and able to live and work 'normally'...." Read more
"...It's not stimulating; it just sets you back to normal...." Read more
"...—up to 30%, by some accounts.3 In many cases, the drugs make depressed individuals feel worse, and FDA-mandated labeling now requires a warning that..." Read more
"...It just makes me feel more calm, peaceful and cheerful. As lame as that sounds it is a tremendous help when dealing with the pain of arthritis...." Read more
Customers find the product easy to use. They mention it helps them work through problems without getting agitated, feel confident, and ready to tackle any projects at work. They also feel less irritable and more eager to do anything.
"...I found it easier to work through problems without getting agitated...." Read more
"...Within 4wks of half a tablet daily, I felt less irritable and more eager to do anything (yes, even stuff I hate)...." Read more
"...This has truly made a difference. I wake up feeling great, ready to face the day. I'm not as sad and weepy as I was before I began taking it...." Read more
"...There were no side effectsI just felt confident and ready to tackle any projects at work without any anxiousness...." Read more
Customers have noticed a difference in their energy level after a week of using the product. They say they are motivated, have more energy, and are able to exercise more.
"...… I feel somewhat more motivated and have noticed a decent bit more energy and focus...." Read more
"...Mood improved, energy level really improved, and I was able to stay focused without anxiety overpowering my thoughts...." Read more
"I think I have noticed a difference in my energy level after a week...." Read more
"...I am walking better and able to exercise more." Read more
Customers are mixed about the stomach pain. Some mention that it helps with body aches and joint pain, while others say that it gave them terrible stomach pains and made them sick all day.
"...associated with antidepressant medications such as weight gain, constipation, dry mouth, and other symptoms that cause many depressives to stop..." Read more
"...with food, and the results seem to be just fine with food, and no real stomach upset that way...." Read more
"...However I developed strange pains in my one arm and one leg that were definitely not caused by injury as well as tingling in the fingers of the arm..." Read more
"...is a lack of pain I sometimes have in my knees and back and it helps my carpal tunnel. I really recommend giving this a try for depression...." Read more
Customers are mixed about the durability of the product. Some mention that it does its job on their body and is well-tolerated, while others say that a few tablets were broken and the capsules cracked.
"...unlike those drugs, SAMe has remarkably few side effects and is well-tolerated even in elderly subjects.8..." Read more
"...I did notice a few tablets were broken which negates the concept of enteric coating for the broken tablets...." Read more
"...Just smooth and steady, focused and able to live and work 'normally'. I mostly hate normal but sometimes, ya know, ya have to...." Read more
"...I personally need the 400 mg. the 200 is not strong enough yet if i double down i blow through them faster also." Read more
Reviews with images
-
Top reviews
Top reviews from the United States
There was a problem filtering reviews right now. Please try again later.
New Human Study Confirms Potent Antidepressant Effects of SAMe
December 2010
By David Hoffnung
Life Extension® introduced SAMe (S-adenosylmethinone) in 1997. Back then it was enormously popular in Europe, but unknown in the United States.
The National Institute of Mental Health decided to fund a double-blind, placebo-controlled trial that would evaluate SAMe as an additive therapy in those suffering major depression who were resistant to FDA-approved drugs.
Researchers at Harvard Medical School and Massachusetts General Hospital gave patients 800 mg of SAMe twice daily along with a selective serotonin reuptake inhibiting drug (SSRI).
Relative to placebo, patients who received the SAMe showed a 105% higher response rate and a 121% higher remission rate.1 Said differently, add-on therapy with SAMe in patients with drug-resistant depression produced double the response rate AND remission rate compared with placebo within a 6-week period.
This study was published in the August 2010 issue of the American Journal of Psychiatry.1 It was a follow-up to a 2004 pilot study that showed greater benefits when antidepressant drugs were combined with SAMe than when the same drugs were taken alone.2
For the past 13 years, SAMe has been on Life Extension’s TOP TEN list of the most important steps to take to ensure optimal longevity. SAMe has been recommended to aging individuals not to just feel better, but also to protect the brain, liver, joints, and other tissues of the body like no other substance.
This article reviews and updates the many studies documenting the anti-aging properties of SAMe.
A listing of all the drugs the FDA has approved to treat depression would fill several pages of this magazine. A major problem with these antidepressant drugs is that they fail a significant number of patients—up to 30%, by some accounts.3 In many cases, the drugs make depressed individuals feel worse, and FDA-mandated labeling now requires a warning that use of some antidepressants increases suicide risk—which is an incredible contradiction considering that suicide is a leading cause of death amongst depressives.
An equally disconcerting issue is the many side effects associated with antidepressant medications such as weight gain, constipation, dry mouth, and other symptoms that cause many depressives to stop using them.
There is thus an urgent need for a new approach to treating those who fail to respond to currently available antidepressant medications. Encouraging news from a recent study shows that the addition of S-adenosylmethinone (SAMe) to a serotonin reuptake inhibitor drug markedly improves the percentage of severe depressives who are relieved of their disorder.
Unlike synthetic prescription drugs that induce unintended side effects, SAMe is a naturally-occurring agent in the body that performs a multitude of beneficial functions, such as boosting glutathione levels in the brain and liver. The anti-aging properties of SAMe are so profound that non-depressives take it each day (in lower doses) just like they do their other dietary supplements.4,5
Antidepressants Don’t Work
As a team of Harvard researchers noted in a remarkable 2010 study published in the Journal of Clinical Psychiatry,6 “The majority of depressed patients will not experience remission when treated with a first-line antidepressant.”
In other words, antidepressants don’t really work for most patients. More is needed to help depression’s victims.
This is where SAMe comes in.
In modern high-tech imaging studies of healthy human brains, SAMe produces effects typical of several classes of antidepressant drugs7—but unlike those drugs, SAMe has remarkably few side effects and is well-tolerated even in elderly subjects.8
People with depression may exhibit a variety of biochemical imbalances, but the most common and best-known has to do with neurotransmitters like serotonin (involved in mood, sleep, appetite, and learning) and norepinephrine (involved in heart rate, blood pressure, and the fight-or-flight response). These chemical messengers belong to a class of molecules known as monoamines, and their synthesis in brain cells is largely controlled by the presence of folic acid, vitamin B12—and SAMe.9-12 When released into the space between brain cells (the synapse), monoamines exert stimulating or inhibiting effects on postsynaptic neurons.
With too little serotonin or norepinephrine available, the brain cannot sustain a positive mood—and depression results. Virtually all antidepressant drugs work to boost levels of these neurotransmitters within the synapse. And therein lie many of their limitations—and the causes of many of their side effects.13
SAMe operates through a completely different mechanism than these drugs. A molecule derived from the sulfur-containing amino acid methionine, SAMe is found in every living cell and plays a central role in cellular function.14,15 In addition to being required for monoamine synthesis, it also affects cell membrane fluidity, which may in turn influence how well a neuron transmits an electrical signal.16 Recent studies have shown that SAMe is also involved in the so-called “epigenetic” control of cellular function—the ability of cells to activate or suppress specific genes based on environmental influences—by its effects on proteins associated with chromosomes.17
These multi-targeted effects, coupled with an extraordinary safety profile, make SAMe a compelling treatment for a wide variety of brain disorders, from depression and cognitive decline to congenital metabolic dysfunction.18,19 SAMe crosses the blood-brain barrier, making it readily available to the brain and nervous system.10 This is vital: SAMe levels in the spinal fluid of depressed individuals have been shown to be significantly lower than those of healthy people.11
Animal models of depression shed additional light on how SAMe works in the brain. More than two decades ago Japanese scientists demonstrated a reduction in aggression in rats treated with SAMe as a result of its action in the central nervous system.20 By the turn of this century, researchers in Italy and Spain showed that SAMe reverses experimentally-induced depression in rats, at a rate faster than that of the prescription antidepressant imipramine, the first tricyclic antidepressant developed, and without apparent side effects.21,22 And in a remarkably detailed study, the Italian group showed that SAMe restored diminished brain levels of “polyamines,” essential brain molecules that are reduced in depressed patients.23
In 2007 a team of scientists at the University of Massachusetts launched a study using a combination of SAMe with N-acetyl cysteine (NAC) and acetyl-L-carnitine.24 Their subjects were aging mice with neurodegeneration similar to Alzheimer’s disease, in which depression is often a major manifestation. The combination rapidly enhanced cognitive function and prevented or reduced aggression in the animals, an effect that was rapidly reversed when the combination was withdrawn. The combination also prevented a decline in levels of the neurotransmitter acetylcholine, while contributing important antioxidant effects as well.
WHAT YOU NEED TO KNOW: SAME
• A landmark study funded by the National Institute of Mental Health revealed that the addition of S-adenosylmethionine or SAMe produces compelling results in people taking SSRIs, the majority of whom do not experience relief when taking the drug alone.
• SAMe is a naturally occurring molecule found in all living cells; it supports a host of chemical functions necessary for normal brain activity.
• SAMe acts by several distinct and independent mechanisms to target multiple sites of action in brain cells that are involved in producing depression.
• In clinical trials, SAMe has been shown to be at least as effective as prescription antidepressants, but with far fewer side effects.
• Because of its strong safety record, SAMe should be part of any regimen for brain health, particularly when depressive symptoms are present—and when prescription drugs alone don’t work.
• SAMe has also been shown to confer enormous benefits to the brain, liver, and joints, halting and even reversing various degenerative conditions, from osteoarthritis and neurodegeneration to nonalcoholic fatty liver disease.
http://www.lifeextension.com/magazine/2010/12/new-human-study-confirms-potent-antidepressant-effects-of-same/page-01
After about three or four days of just 400 mg total per day, I noticed I was having trouble sleeping at night. Had tons of energy at bedtime, and then started to notice some dizziness. I didn't attribute the dizziness to the Sam-E at 1st, but after I got off it for a day or two it cleared up so I have to attribute it to the Sam-E.
I also found for me I'm better off taking it with food, and the results seem to be just fine with food, and no real stomach upset that way.
It's hard to say how long this medication will work. If the body adapts to it, etc. but for the short time I've been on it it seems like a wonder drug. Just be very careful of the dosage. I think nature craft has a 150 mg version, and I may switch over to that as 400 mg a day for me is too much. I can't imagine how people are taking 1200mg +.
And this is definitely not candy. Be very careful with your dosage. I would say start small and build up. If you suffer from anxiety and/or depression, well worth giving it a shot. Nature craft has a smaller $26 bottle as well, and it works you can always go to a larger bottle.
I used the "Now" brand for a few different things now and it seems to be a pretty reputable brand. I like the nature craft as well.
I’m tried tyrosine, phenylalanine, 5-htp… b12, GABA, so on. None of them did much at all. Definitely nothing I couldn’t live without.
Somehow came across this and although I’d heard of it many times, I’d never tried it.
Once again aiming for relief, I gave this a shot and I’m now 1 month in and I’m very surprised with the positive results. It’s not a miracle, but my brain fog has significantly lifted, I sleep better- I wake up a bit easier (not EASY, but I come to alertness quicker vs. laying there feeling so groggy and hitting snooze 100x- now I only hit it 25x haha)… I feel somewhat more motivated and have noticed a decent bit more energy and focus. I normally have to force myself to get things done, if I can even do that.
I’m also now able to stay up about an hour later each night, with more productivity after work rather than immediately plopping down on the bed after barely making it home awake.
I started with 400mg but found that didn’t quite get me there so I now take 2 of them on an empty stomach around waking. I handle that well. I’ve always been someone that needed huge doses of ADD medicines and antidepressants anyway so I’m not surprised there. I feel I could probably even do 1,200mg a day, but I have a good thing going so far and don’t want to mess it up with too much anxiety etc.
It did take several weeks for the effect to come on, so don’t give up quickly and try 400mg for a few weeks before deciding to go up. I have learned that it truly is possible to take too much of something and it will have the dead opposite (and bad) effect of a beneficial lower dose. Examples for me- too much ADD medicine makes me sleepy, unfocused and unmotivated. Too much caffeine makes me sleepy and cloudy headed. So don’t overdo it too quick and skip past your ideal dose!
I found I did experience some high anxiety and some trouble falling asleep a week or so in but I was under high stress at the time so I’m not sure it was due to this.
But to anyone who hasn’t found relief with other supplements and suffer similar symptoms, I say: definitely give this a try and be patient. I am not very susceptible to the placebo effect since I’ve been so let down by so many supplements over the years. This one actually does something, at least for me.
Hope it works for you as well.
Disclaimer: While we work to ensure that product information is correct, on occasion manufacturers may alter their ingredient lists. Actual product packaging and materials may contain more and/or different information than that shown on our Web site. We recommend that you do not solely rely on the information presented and that you always read labels, warnings, and directions before using or consuming a product. For additional information about a product, please contact the manufacturer. Content on this site is for reference purposes and is not intended to substitute for advice given by a physician, pharmacist, or other licensed health-care professional. You should not use this information as self-diagnosis or for treating a health problem or disease. Contact your health-care provider immediately if you suspect that you have a medical problem. Information and statements regarding dietary supplements have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent any disease or health condition. Amazon.com assumes no liability for inaccuracies or misstatements about products.