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NOW Supplements, SAMe (S-Adenosyl-L-Methionine) 400 mg, Nervous System Support*, 60 Tablets

4.5 4.5 out of 5 stars 669 ratings

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60 Count (Pack of 1)

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About this item

  • NEW OVAL TABLET!: SAMe (S-adenosylmethionine), a compound native to the body, is a component of many biochemical reactions, including those that affect brain biochemistry and joint health.*
  • SUPPORTS NERVOUS SYSTEM, EMOTIONAL WELL-BEING, AND JOINT HEALTH*: Numerous studies have indicated that SAMe can help to alleviate transient minor aches and pains resulting from overexertion or strain.* In addition, because SAMe is also necessary for the synthesis of neurotransmitters, it plays an important role in mood support.*
  • CERTIFICATIONS/CLASSIFICATIONS: Dairy Free, Egg Free, Made without Gluten, Soy Free, Sugar Free, Vegan/Vegetarian
  • GMP Quality Assured: NPA A-rated GMP certification means that every aspect of the NOW manufacturing process has been examined, including our laboratory/testing methods (for stability, potency, and product formulation).
  • Packaged in the USA by a family owned and operated company since 1968
  • During the summer months products may arrive warm but Amazon stores and ships products in accordance with manufacturers' recommendations, when provided.

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Product Description

Product Description

SAMe (S-adenosylmethionine), a compound native to the body, is a component of many biochemical reactions, including those that affect brain biochemistry and joint health.* Numerous studies have indicated that SAMe can help to alleviate transient minor aches and pains resulting from overexertion or strain.* In addition, because SAMe is also necessary for the synthesis of neurotransmitters, it plays an important role in mood support.* NOW® SAMe is enteric-coated, which makes it very well tolerated and protects it from degradation. Natural color variation may occur in this product. Take 1 tablet 2 to 4 times daily, preferably on an empty stomach. Refrigeration recommended after opening.

Brand Story

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Product details

  • Is Discontinued By Manufacturer ‏ : ‎ No
  • Product Dimensions ‏ : ‎ 2.13 x 2.13 x 4 inches; 3.17 ounces
  • Item model number ‏ : ‎ 0141
  • Department ‏ : ‎ Health and Beauty>Health and Wellness
  • Date First Available ‏ : ‎ October 3, 2006
  • Manufacturer ‏ : ‎ NOW Sports - Nutrition and Wellness
  • ASIN ‏ : ‎ B000OSSQFY
  • Country of Origin ‏ : ‎ USA
  • Customer Reviews:
    4.5 4.5 out of 5 stars 669 ratings

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NOW Supplements, SAMe (S-Adenosyl-L-Methionine) 400 mg, Nervous System Support*, 60 Tablets
NOW Supplements, SAMe (S-Adenosyl-L-Methionine) 400 mg, Nervous System Support*, 60 Tablets
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Price-41% $42.79
List:$71.99
-15% $23.99
List:$28.22
$35.95-13% $23.77
List:$27.34
$18.97-44% $34.75
List:$62.19
Price Per Unit$0.71 / Count$0.40 / Count$0.30 / Count$0.40 / Count$0.32 / Count$0.97 / Count
Delivery
Get it as soon as Tuesday, Mar 26
Get it as soon as Tuesday, Mar 26
Get it as soon as Tuesday, Mar 26
Get it as soon as Tuesday, Mar 26
Customer Ratings
Easy to swallow
4.2
4.3
4.2
4.7
4.7
4.2
Pain relief
3.0
3.2
3.5
4.0
3.5
Value for money
3.7
4.8
4.4
3.8
Flavor
4.0
4.2
4.5
4.0
Sold By
Amazon.com
Carlyle
eSupplements
Natures Craft Deals
Motivated Mindset
Certified Wholesale Market
keyword type
multiple-vitamin-mineral-combinations
multiple-vitamin-mineral-combinations
multiple-vitamin-mineral-combinations
multiple-vitamin-mineral-combinations
elderberry-herbal-supplements
multiple-vitamin-mineral-combinations
form
Tablet
Tablet
Capsule
Capsule
Gummy
Tablet
flavor
Unflavored
Unflavored
No Artificial Flavors
size
60 Count (Pack of 1)
60 Count (Pack of 1)
120 Count (Pack of 1)
60 Count (Pack of 1)
60 Count (Pack of 1)
36 Count (Pack of 1)
weight
0.2 pounds
5.26 ounces
0.07 kilograms
0.01 ounces
0.15 pounds
age range
Adult
Adult
Adult
Adult
Adult
Adult
product benefit
Bone & Joint Support
Detoxing
Mood Support,Joint Support

Important information

Safety Information

For adults only. Keep out of the reach of children. Individuals with bipolar (maniac) depression and these with anxiety disorder should not take SAMe unless under professional medical supervision. Consult physician if pregnant/nursing, taking medication, or have a medical condition. Do not eat freshness packet. Keep in bottle. Refrigeration recommended after opening. Allergen Caution: Product not manufacture with wheat, gluten, soy, milk, egg, fish, shellfish, or tree nut ingredients.This product is labelled to United States standards and may differ from similar products sold elsewhere in its ingredients, labeling and allergen warnings

Ingredients

Supplement FactsServing Size:1 TabletServings Per Container:30DescriptionAmount per Serving% Daily ValueSAMe (S-Adenosyl-L-Methionine)(from S-Adenosyl-L-Methionine Disulfate Tosylate) 400 mg ** Daily Value not established. **Daily Value not established.Other Ingredients: Microcrystalline Cellulose, Stearic Acid (vegetable source), Pharmaceutical Glaze, Magnesium Stearate (vegetable source), Silicon Dioxide, Glycerin, Sodium Alginate and L-Arginine. Not manufactured with wheat, gluten, soy, milk, egg, fish or shellfish ingredients. Produced in a GMP facility that processes other ingredients containing these allergens. Caution: For adults only. Individuals with bipolar depression, anxiety disorders or taking antidepressant medications should not take SAMe unless under professional medical supervision. Consult physician if pregnant/nursing, taking medication, or have a medical condition. Keep out of reach of children. Natural color variation may occur in this product. Made and quality tested in the USA with globally sourced ingredients. Family owned since 1968.

Directions

Take 1 tablet 2 to 4 times daily, preferably on an empty stomach.

Legal Disclaimer

These statements have not been evaluated by the Food & Drug Administration. This products is not intended to diagnose, cure, mitigate, treat, or prevent any disease.

Statements regarding dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease or health condition.

Looking for specific info?

Customer reviews

4.5 out of 5 stars
4.5 out of 5
669 global ratings

Customers say

Customers like the performance, quality and value of the health personal care product. They mention that it helps with mood boost, brings homeostasis to the hypothalamus and that it's the best quality for the money. Customers also say that it makes them feel more calm, peaceful and cheerful. However, some customers differ on stomach pain, and durability.

AI-generated from the text of customer reviews

85 customers mention76 positive9 negative

Customers like the performance of the product. They say it helps with mood boost, improves mood and sleep instantly, and helps their body function. They also mention that it brings homeostasis to the hypothalamus, which helps regulate body temp. Customers also say it gives them energy and calms their nerves. They are surprised with the positive results and say the combination rapidly enhanced cognitive function and prevented or reduced aggression.

"...The combination rapidly enhanced cognitive function and prevented or reduced aggression in the animals, an effect that was rapidly reversed when the..." Read more

"...I gave this a shot and I’m now 1 month in and I’m very surprised with the positive results...." Read more

"...I believe on the second day I noticed an improvement. Mood improved, energy level really improved, and I was able to stay focused without anxiety..." Read more

"I feel Sam-e absolutely helped me with my depression...." Read more

46 customers mention46 positive0 negative

Customers are satisfied with the quality of the health supplement. They mention that it works well, is a reputable brand, and is well-made. Some say that the product arrived in good shape. Overall, customers are happy with their purchase and recommend it to others.

"...Because of its strong safety record, SAMe should be part of any regimen for brain health, particularly when depressive symptoms are present—and when..." Read more

"...Now" brand for a few different things now and it seems to be a pretty reputable brand. I like the nature craft as well." Read more

"...Just smooth and steady, focused and able to live and work 'normally'. I mostly hate normal but sometimes, ya know, ya have to...." Read more

"...The dose was worked out by my vet. They go fairly quickly. More economically feasible to buy these bottles in pairs to save on shipping." Read more

27 customers mention21 positive6 negative

Customers like the value of the health personal care product. They say it provides the best quality for the money.

"...it as a subscribe and save option, which does make it more affordable in monthly increments." Read more

"...It's cheaper, and it's clear that it (in combination with another med from Vet) is doing wonders for my dog!..." Read more

"...a higher dosage of this versus the GNC version but this is also much cheaper and a better value." Read more

"...The NOW brand is quality and a great price.If you have chronic pain and want relief give SAMe a try." Read more

10 customers mention7 positive3 negative

Customers like the effect of the product on their body. They say it makes them feel more calm, peaceful, and cheerful. They also say it helps them feel less anxiety, better sleep, and stabilize their emotions. Customers also mention that the product is not stimulating and just sets them back to normal.

"...No highs or lows, no anxiety, no lethargy, no angry outbursts. Just smooth and steady, focused and able to live and work 'normally'...." Read more

"...It's not stimulating; it just sets you back to normal...." Read more

"...—up to 30%, by some accounts.3 In many cases, the drugs make depressed individuals feel worse, and FDA-mandated labeling now requires a warning that..." Read more

"...It just makes me feel more calm, peaceful and cheerful. As lame as that sounds it is a tremendous help when dealing with the pain of arthritis...." Read more

4 customers mention4 positive0 negative

Customers find the product easy to use. They mention it helps them work through problems without getting agitated, feel confident, and ready to tackle any projects at work. They also feel less irritable and more eager to do anything.

"...I found it easier to work through problems without getting agitated...." Read more

"...Within 4wks of half a tablet daily, I felt less irritable and more eager to do anything (yes, even stuff I hate)...." Read more

"...This has truly made a difference. I wake up feeling great, ready to face the day. I'm not as sad and weepy as I was before I began taking it...." Read more

"...There were no side effectsI just felt confident and ready to tackle any projects at work without any anxiousness...." Read more

4 customers mention4 positive0 negative

Customers have noticed a difference in their energy level after a week of using the product. They say they are motivated, have more energy, and are able to exercise more.

"...… I feel somewhat more motivated and have noticed a decent bit more energy and focus...." Read more

"...Mood improved, energy level really improved, and I was able to stay focused without anxiety overpowering my thoughts...." Read more

"I think I have noticed a difference in my energy level after a week...." Read more

"...I am walking better and able to exercise more." Read more

52 customers mention23 positive29 negative

Customers are mixed about the stomach pain. Some mention that it helps with body aches and joint pain, while others say that it gave them terrible stomach pains and made them sick all day.

"...associated with antidepressant medications such as weight gain, constipation, dry mouth, and other symptoms that cause many depressives to stop..." Read more

"...with food, and the results seem to be just fine with food, and no real stomach upset that way...." Read more

"...However I developed strange pains in my one arm and one leg that were definitely not caused by injury as well as tingling in the fingers of the arm..." Read more

"...is a lack of pain I sometimes have in my knees and back and it helps my carpal tunnel. I really recommend giving this a try for depression...." Read more

6 customers mention3 positive3 negative

Customers are mixed about the durability of the product. Some mention that it does its job on their body and is well-tolerated, while others say that a few tablets were broken and the capsules cracked.

"...unlike those drugs, SAMe has remarkably few side effects and is well-tolerated even in elderly subjects.8..." Read more

"...I did notice a few tablets were broken which negates the concept of enteric coating for the broken tablets...." Read more

"...Just smooth and steady, focused and able to live and work 'normally'. I mostly hate normal but sometimes, ya know, ya have to...." Read more

"...I personally need the 400 mg. the 200 is not strong enough yet if i double down i blow through them faster also." Read more

Capsules cracked & leaking...
2 Stars
Capsules cracked & leaking...
Capsules showed up cracked and leaking. Not sure if this was because of heat or packing but make sure to check inside the bottle while you are still within your return period!
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Disclaimer: While we work to ensure that product information is correct, on occasion manufacturers may alter their ingredient lists. Actual product packaging and materials may contain more and/or different information than that shown on our Web site. We recommend that you do not solely rely on the information presented and that you always read labels, warnings, and directions before using or consuming a product. For additional information about a product, please contact the manufacturer. Content on this site is for reference purposes and is not intended to substitute for advice given by a physician, pharmacist, or other licensed health-care professional. You should not use this information as self-diagnosis or for treating a health problem or disease. Contact your health-care provider immediately if you suspect that you have a medical problem. Information and statements regarding dietary supplements have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent any disease or health condition. Amazon.com assumes no liability for inaccuracies or misstatements about products.