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Brain Maker: The Power of Gut Microbes to Heal and Protect Your Brain for Life Hardcover – Illustrated, April 28, 2015

by David Perlmutter MD (Author)
4.6 4.6 out of 5 stars 3,705 ratings
Goodreads Choice Award nominee
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The bestselling author of Grain Brain uncovers the powerful role of gut bacteria in determining your brain's destiny.

Debilitating brain disorders are on the rise-from children diagnosed with autism and ADHD to adults developing dementia at younger ages than ever before. But a medical revolution is underway that can solve this problem: Astonishing new research is revealing that the health of your brain is, to an extraordinary degree, dictated by the state of your microbiome - the vast population of organisms that live in your body and outnumber your own cells ten to one. What's taking place in your intestines today is determining your risk for any number of brain-related conditions.

In Brain Maker, Dr. Perlmutter explains the potent interplay between intestinal microbes and the brain, describing how the microbiome develops from birth and evolves based on lifestyle choices, how it can become "sick," and how nurturing gut health through a few easy strategies can alter your brain's destiny for the better. With simple dietary recommendations and a highly practical program of six steps to improving gut ecology, Brain Maker opens the door to unprecedented brain health potential.
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Previous page
  1. Print length
    320 pages
  2. Language
    English
  3. Publisher
    Little, Brown Spark
  4. Publication date
    April 28, 2015
  5. Dimensions
    6.5 x 1.25 x 9.75 inches
  6. ISBN-10
    0316380105
  7. ISBN-13
    978-0316380102
  8. See all details
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Editorial Reviews

Review

"Dr. Perlmutter's book is among those rare and exciting exceptions: information so empowering, so enlightening, and presented so clearly and concisely that the reader emerges far better off for the reading experience. Put this book on your short list of must-reads for health and nutrition."—William Davis, MD, author of Wheat Belly

"The research in Brain Maker was a revelation to me. And it will be to you as well. And, most importantly, you don't have to wait for this information to become mainstream. You can ensure your brain health-and that of your family-by following the practical program outlined here."—Christiane Northrup, MD, author of Women's Bodies, Women's Wisdom and Goddesses Never Age

"The single most important medical innovation in the 21st century is making the link between the gut and the little bugs that live there and nearly every chronic disease - from autism to depression, from asthma to autoimmune disease, from diabetes to dementia. Brain Maker is a game changer. For the first time, this brilliant scientist doctor connects the dots and teaches us why we need to tend our inner garden (our microbiome) and provides a radical but simple plan to reset, reboot, and renew your microbiome. This book shouldn't be called Brain Maker, it should be called Health Maker."—Mark Hyman, MD, author of The Blood Sugar Solution

"Thanks in large part to dramatic and ongoing increases in understanding the brain-gut-microbiome connection, there is new hope for the treatment of many neurological conditions, from autism to Alzheimer's to multiple sclerosis. David Perlmutter is a leader in this burgeoning field, and his new book, Brain Maker, is a landmark contribution."—Dale E. Bredesen, MD, professor and director of Alzheimer's Disease Research, UCLA

"In this revolutionary new book, the nation's leading integrative neurologist, David Perlmutter, gives you a powerful program to heal your gut and optimize your brain. I will recommend it to all of my patients and friends."—Daniel G. Amen, MD, founder of Amen Clinics and author of Change Your Brain, Change Your Life and Healing ADD

 "Bravo! Dr. Permutter's latest paradigm-shifting book shows us how to manage our health, and especially our brains, through the new frontier of science, the microbiome. By connecting the dots from our gut to our brain, he explains how we can avoid disease, age well, handle stress, and manage our moods. With revolutionary ideas and practical advice, he gives us a fighting chance against brain decline. I love this book!"—John Ratey, MD, author of Spark and coauthor of Go Wild, Clinical Professor of Psychiatry, Harvard Medical School

"Dr. Perlmutter engagingly explains the hope-generating power of the new gut microbiome-brain science, motivating you to regenerate your brain health with his powerful and practical program."—Martha Herbert, MD, PhD, Assistant Professor of Neurology, Harvard Medical School

PRAISE FOR GRAIN BRAIN

"An innovative approach to our most fragile organ, the brain."—Mehmet Oz, MD

"Dr. Perlmutter makes a persuasive case for this wheat-free approach to preserve brain health and functioning, or to begin the process of reversal."—William Davis, MD, author of Wheat Belly

"The definitive instruction book for the care and feeding of your brain!"—Mark Hyman, MD, author of The Blood Sugar Solution

"Gives you everything you need to know to protect your brain--or a loved one's--now."—Christiane Northrup, MD, author of Women's Bodies, Women's Wisdom

"This book is a treasure."—Bernie Siegel, MD, author of Faith, Hope, and Healing and The Art of Healing

"A provocative, eye-opening scientific account of how diet profoundly influences nerve health and brain function. A must-read!"—Gerard E. Mullin, MD, Associate Professor of Medicine, The Johns Hopkins School of Medicine, and author of The Inside Tract

"Mind-blowing and disruptive to some long-standing beliefs about what our bodies require for optimal health...Grain Brain lays out an easy-to-understand roadmap packed with the latest science."—Max Lugavere, Psychology Today

"A tour de force that is destined to save many lives. [Grain Brain] gives us what we need to know to be well again. Please read it."—Health Central

About the Author

David Perlmutter, MD, is a board-certified neurologist and a Fellow of the American College of Nutrition. He was the recipient of the Linus Pauling Award for his innovative approaches to neurological disorders. With his books now published in twenty-seven languages, Dr. Perlmutter is setting new standards for what healthy lifestyle means around the world.

He is the author of the New York Times bestsellers Grain Brain, The Grain Brain Cookbook, and Brain Maker, as well as The Better Brain Book and Raise a Smarter Child by Kindergarten. He lives in Naples, Florida.

Product details

  • Publisher ‏ : ‎ Little, Brown Spark; Illustrated edition (April 28, 2015)
  • Language ‏ : ‎ English
  • Hardcover ‏ : ‎ 320 pages
  • ISBN-10 ‏ : ‎ 0316380105
  • ISBN-13 ‏ : ‎ 978-0316380102
  • Item Weight ‏ : ‎ 1.15 pounds
  • Dimensions ‏ : ‎ 6.5 x 1.25 x 9.75 inches
  • Customer Reviews:
    4.6 4.6 out of 5 stars 3,705 ratings

About the author

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David Perlmutter

David Perlmutter

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David Perlmutter, MD, FACN, ABIHM is a Board-Certified Neurologist, Fellow of the American College of Nutrition and six time New York Times bestselling author. He received his M.D. degree from the University of Miami School of Medicine where he was awarded the Leonard G. Rowntree Research Award. Dr. Perlmutter is a frequent lecturer at symposia sponsored by such medical institutions as Columbia University, the University of Arizona, Scripps Institute, and Harvard University. He has contributed extensively to the world medical literature with publications appearing in The Journal of Neurosurgery, The Southern Medical Journal, Journal of Applied Nutrition, and Archives of Neurology. He is the author of the #1 New York Times Bestseller, Grain Brain. Other New York Times bestsellers include Brain Maker, The Grain Brain Cookbook, The Grain Brain Whole Life Plan and New York Times bestseller, Brain Wash (January, 2020) co-written with his son, Austin Perlmutter, MD. He is recognized internationally as a leader in the field of nutritional influences in neurological disorders. Dr. Perlmutter has been interviewed on many nationally syndicated radio and television programs including 20/20, Larry King Live, CNN, Fox News, Fox and Friends, The Today Show, Oprah, Dr. Oz, and The CBS Early Show. In 2002 Dr. Perlmutter was the recipient of the Linus Pauling Award for his innovative approaches to neurological disorders and in addition was awarded the Denham Harmon Award for his pioneering work in the application of free radical science to clinical medicine. He is the recipient of the 2006 National Nutritional Foods Association Clinician of the Year Award. Most recently, Dr. Perlmutter was awarded the 2019 Global Leadership Award form the Integrative Healthcare Symposium. In December of 2017, Dr. Perlmutter lectured at the World Bank with his presentation broadcasted to 150 sites around the world. His books are now published in 36 languages. His latest work, New York Times bestseller, Drop Acid (February 15, 2022), explores how elevated uric acid powerfully threatens metabolic health, and how it can be brought under control.

Customer reviews

4.6 out of 5 stars
4.6 out of 5
3,705 global ratings
Wonderful and life changing book (s)
5 Stars
Wonderful and life changing book (s)
I found especially Brain Maker a life changing book. I actually purchase two version of each of the books - I love Audio CD books so I can relax at night and physical book as reference book. So far I have gone though Brain Wash first and recently Brain Maker and planned to do Grain Brain ( which I had hard cover for long time ) starting tonight. For myself I found the best technique is to relax at night before bed.Some informtion on my self, I am almost 59 year male that found out 13 years ago - I was an Asperger which is mild highly functional version of Autism. I been and still am a successful computer developer and problem solver. I have found the Latin dancing has help and even performed last September but to do this I had to change my nutrition so I can do this. Though this dancing, I was introduce to Isagenix program and made significant changes to myself. My major problem is sleep issues and I was taking ZZZQuil and one night my body rejected and ever since that night a month ago, I been off and finding a better way.Part of my research came about the these books and it make logical since that the ZZZQuil is bad for my system and listening to probiotics, this make sense. The biggest issue is my sleep issues and so far, I have not completely resolved this issue but I have hope in future that I will be able to over come this program.I truly believe the words in this book is part of the solution for Asperger and my sleeping issues. I also believe what I doing which is slightly modified Isagenix plan is signficant to this solution. I look forward to future book by David and highly recommend his books.
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Top reviews from the United States

Gideon Saunders
5.0 out of 5 stars Groundbreaking in increasing awareness of the importance of a healthy gut biome.
Reviewed in the United States on April 17, 2017
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Dr. Perlmutter scores again with a great book, this time about the profound impact of gut flora on our health. As patients and people we have been taught that having a propensity to get fat, dementia or cancer is “genetic” and we are mostly helpless to change that. Yet, the research shows that our second genome, that of our gut population, could be a much more relevant and powerful factor than our own human genome.

David Perlmutter enjoys a privileged position of being a physician, therefore people listen to him. This information is well cited, based on research and brings it to the masses with his approachable, conversational style as well as his unabashed enthusiasm for the potential of treatments and cures for his patients. He starts with the research that makes foundational concepts: sterile mice implanted with gut flora from slender mice stay lean, mice implanted with obese mice get fat when given the same diet and environment. Then he expands to the more abstract information like the detrimental effects of antibiotics and the study that showed women who have undergone the most days on antibiotics have twice the rate of breast cancer. He shows how poor gut health causes high blood sugar, inflammation, decreased resilience to stress, sleep and cognitive difficulties and more.

The angle that is original in this book is the relationship of gut dysbiosis and brain diseases and practical application of gut healing. People suffering from major depression, Alzheimer’s and autism have high rates of gut dysbiosis. In his practice, when he corrects the gut imbalance in people with these and other neurological diseases, symptoms often decrease or sometimes disappear. These are diseases with no accepted “cure”. He peppered his book with anecdotal reports of his patients having mind blowing transformations like these after taking very intentional steps such as diet modification, eating fermented foods and even probiotic enemas. Hopefully there will be some real research in this area someday. His epilogue seems optimistic that sufficient research will happen. I doubt this field is getting the true attention it deserves. He shows no criticism towards the “system” at the fact that fecal transplants are only approved for C.diff patients yet people with IBS and other diseases get radically great results from them. He matter of factly tells us sends his patients that need a fecal transplant overseas. Well good for those who have the luxury of seeing the celebrity doctor then jet set to Europe to get their treatment. What about the rest of people suffering?

I think this book is great in the way it shows the whole picture of the gut flora from the negative effects of cesarean birth, rounds of antibiotics, chemical exposure and a western diet. He clearly outlines a path to reversing a damaged gut. The one criticism I have is that he recommends a high fiber diet heavy with fermented foods and includes a week long diet plan. He also give instruction on how to ferment to make this lifestyle affordable and accessible to all. However, adding 3 servings a day of billions of bacteria a day can cause digestive distress to most people accustomed to the standard American diet. I would recommend a gradual introduction instead.

Overall, it’s a great book. It’s well cited, clearly organized. He quotes top scientists and researchers that all share his enthusiasm for this frontier of healing and understanding the human body. It’s not dumbed down yet it’s understandable enough for the common reader. This book will be groundbreaking in increasing awareness of this emerging field that affects us all.
66 people found this helpful
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horse girl
5.0 out of 5 stars Great information! Highly recommended!
Reviewed in the United States on May 20, 2015
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This book reinforced all that I had read online and was experiencing in my own life. I crashed BIG time (neurological symptoms)! After blood tests revealed nothing wrong, I looked elsewhere and eliminated gluten to see improvement in my health and a friend recommended Wheat Belly, another great book and one that Dr. Perlmutter references in his first book, Grain Brain. I enjoyed that so much that I went on to read Grain Brain and then Wheat Belly Total Health and then this, Brain Maker.

Throughout all this reading, I was having further issues with my health and looking for answers while eliminating more foods until I finally saw a turnaround. By the time I read BRAIN MAKER, I had learned a great deal online and in these books. All of it has been invaluable information that led me on a journey to understanding what was happening to me and why I was improving with each change I made. Brain Maker gets into details that helped further my education and reinforced the necessary changes I had made in my diet. After making adjustments to my gut flora through diet and finding the right probiotics and realizing that all my symptoms matched a candida overgrowth (and I had been a sugar/grain addict before I crashed--perfect food for the bad gut bugs), I have recovered and am feeling wonderful and adding back in healthy whole foods that I couldn't tolerate for a while. Based on Dr. Perlmutter's recommendation, I added coconut oil to my cooking and fish oil supplements and these have made a positive impact. For a while, I could not tolerate fermented foods or enjoy the teas I love, but that has improved also and I will be adding them back based on his recommendations.

All my life, I've had digestive issues and memory problems and depression that have grown worse over the last fifteen years and also started having anxiety attacks. I attributed these to getting older (I'm 40 now). However, since my big crash and changing my diet, that has improved, along with my sleep (always had a problem with insomnia). I'm so happy that I can more fully follow his diet recommendations, because what I've been able to experience of it so far has been magnificent.

And best yet, I feel good to recommend these books because he is an MD and a neurologist at that. I also like that he grants for special situations where not everyone is going to see the same results, depending on their specific conditions and situations, that each of us is different.

Also, he recommends high amounts of vitamin D but new studies show that vitamin K is also needed to metabolize vitamin D, which is not mentioned in the book. This can be found in leafy greens and other veggies that are recommended on his diet. And some of us are sensitive enough to anything that we don't need to use as much as he recommends. The caveat here is to make adjustments for your particular metabolism.

I love this book and had already implemented 90% of it into the changes I had made to feel twenty years younger and more creative than I can remember being in a long time. This book is a worthwhile read. I love that he uses studies data, anecdotes and examples from his own practice, and recipes. He presents the information fairly, even going so far as to acknowledge that in studies, a relationship in data does not imply causation and doesn't just imply that it supports his point.
89 people found this helpful
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Honuette
4.0 out of 5 stars and believe everyone needs to intelligently adjust a touted way of eating to fit their ...
Reviewed in the United States on May 5, 2016
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The main thing about this book is it gave me clear reasons and enough motivation to actually stop eating sugar and high glycemic carbs. That's huge. It also made me stop eating gluten, and got me to incorporate prebiotics and probiotics. I doubt that there's a one-size-fits-all diet, however, and believe everyone needs to intelligently adjust a touted way of eating to fit their particular situation. My sense is that the good fats on this diet could help one's nervous system and brain function, but I'd still want to be careful not to eat a lot of meat and dairy until it's clearer that animal fats and associated rise in cholesterol do not create their own set of problems.
12 people found this helpful
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Johan Horak
5.0 out of 5 stars Amazing book. Love the truth.
Reviewed in the United States on January 6, 2024
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Reading this book was a pleasure. It's very obvious that the author is a caring man. He is interested in healing. He knows how to identify an issue, and how to heal it. The book is written so that ordinary folks can understand everything. The cases are motivated and and the suggestions to fix it are practical. For example, how many times have I bought over the counter probiotics. Probably a waste. I also like all the recipes to ferment various stuff.
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Top reviews from other countries

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Rodrigo Ortega
5.0 out of 5 stars Muy buen libro
Reviewed in Mexico on July 2, 2019
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Muy buen libro b
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Franco Pontecorvi
5.0 out of 5 stars Libro molto utile
Reviewed in Italy on May 29, 2017
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Il libro è di estremo interesse. La ricerca è solo agli inizi ma è indubitabile che il microbioma è responsabile di un grandissimo numero di patologie. Consiglio l'acquisto.
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Kerrin Simpson
5.0 out of 5 stars Great book, only one criticism.
Reviewed in Australia on November 17, 2016
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Great book, highly informative. Has helped me to better understand the connection between good health and gut microbes.. I bought the Kindle version but also ended up buying the hard copy too. One criticism though, I didn't like all of the comments as to how me "evolved" to be that way. This is not an area of expertise for Dr Perlmutter and it would be better if he left those things unsaid. They were completely unnecessary in the whole scheme of things. But aside from that, very good.
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Renato Rocha
5.0 out of 5 stars Excellent!
Reviewed in Brazil on February 4, 2016
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Excellent!! Very useful information. For your life! Everyone should had the chance to read it! Also a good gift, for sure!
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Patrick Sullivan
5.0 out of 5 stars Gut Management
Reviewed in Canada on May 11, 2015
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This book is all about, the guardianship of the bacteria contained in our digestive track. The evolution of these microbes, has taken millions of years to develop. Dr. Perlmutter points to evidence suggesting, many new additions to our diet, have disrupted the beneficial aspects of our stomach bacteria. He believes it is possible problems like; Alzheimer`s disease, cancer, depression, and even autism, have been caused by imbalances in our digestive biome. Recently created foods like; high fructose corn syrup, over use of antibiodics, pesticide residues in our food supply, are just a few examples of negative new additions to our diet.

Dr. Perlmutter points out, that none of these disease links to gut bateria have been proven. Yet the reader will find themselves drawn to Dr. Perlmutter over all theme. The proper management of our digestive track, will help with one`s general health condition. He lays out all sorts of dietary suggestions. Certain foods contain probiotics and there are several probiotic supplements listed in the book.

There were some repetition issues in the book. Some areas of interest were left out. For instance, does taking a vitamin supplement affect the biodiversity contained in our digestive system? On the same note, do probiotic supplements act differently then natural foods containing probiotics? These were just a few of the questions, the reader will be left wondering about.

In summary, this is an area of health management, that is not very well known to the general public. Dr. Perlmutter has opened the door, to further insights into this field of human health. It is a short book and a quick read. The reader will take away some rather interesting ideas, regarding our diet and health management.
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